Water → Sulbactam

HRID 354916

Reaktionsgleichung

Reaktionsgleichung von HRID 354916
[CH3:1][C:2]1([CH3:15])[S:6](=[O:8])(=[O:7])[CH:5]2[CH2:9][C:10](=[O:11])[N:4]2[CH:3]1[C:12]([O-:14])=[O:13].[Na+].O.C(=O)(O)[O-].[Na+].S([O-])([O-])(=O)=O.[Na+].[Na+]>S(=O)(=O)(O)[O-].C([N+](CCCC)(CCCC)CCCC)CCC.C(Cl)(Cl)Cl>[CH3:1][C:2]1([CH3:15])[S:6](=[O:7])(=[O:8])[C@@H:5]2[CH2:9][C:10](=[O:11])[N:4]2[C@H:3]1[C:12]([OH:14])=[O:13]

Komponenten

7

Edukt 4

HCID 962WaterHCID 24436Sodium SulfateHCID 516892Sodium BicarbonateHCID 23691718Sodium penicillanate 1,1-dioxide

Produkt 1

HCID 130313Sulbactam

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 94433Tetrabutylammonium hydrogen sulfateKatalysatorHCID 6212ChloroformLösungsmittel

Versuchsvorschrift

To a stirred solution of 2.55 g. of sodium penicillanate 1,1-dioxide in 20 ml. of water was added 3.80 g. of tetrabutylammonium bisulfate. Stirring was continued for 5 minutes and then 20 ml. of chloroform was added. The pH was adjusted to 6.8 with saturated aqueous sodium bicarbonate and then the aqueous layer was saturated with sodium sulfate. The layers were separated and the aqueous layer was extracted with chloroform. The combined chloroform solutions were dried using sodium sulfate and then evaporated in vacuo to give the tetrabutylammonium salt of penicillanic acid 1,1-dioxide.

Aufarbeitung

  1. customThe layers were separated
  2. extractionthe aqueous layer was extracted with chloroform
  3. dry with materialThe combined chloroform solutions were dried
  4. customevaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-ac2e53e3cddb465cb06bb2f8c3814586
Quelldatensatz
uspto-grants-1983_03
Patentnummer
US04377590

Verknüpfte Notizen

Wird geladen…