Formic Acid → 3-(3,4-Dimethoxyphenyl)propionic acid

HRID 36407

Reaktionsgleichung

Reaktionsgleichung von HRID 36407
CC1(C)[O:9][C:7](=[O:8])[CH2:6][C:4](=O)O1.C(=O)[C:12]1[CH:21]=[CH:20][C:17]([O:18][CH3:19])=[C:14]([O:15][CH3:16])[CH:13]=1.C(O)=O.Cl>C(N(CC)CC)C>[CH3:16][O:15][C:14]1[CH:13]=[C:12]([CH2:4][CH2:6][C:7]([OH:9])=[O:8])[CH:21]=[CH:20][C:17]=1[O:18][CH3:19]

Komponenten

6

Edukt 4

HCID 284Formic AcidHCID 313Hydrochloric AcidHCID 8419VeratraldehydeHCID 162492,2-Dimethyl-1,3-dioxane-4,6-dione

Produkt 1

HCID 750193-(3,4-Dimethoxyphenyl)propionic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8471TriethylamineLösungsmittel

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

After weighing 14.4 g (0.1 mol) of Meldrum's acid and 16.6 g (0.1 mol) of veratraldehyde to 50 ml of the mixture of formic acid and triethylamine prepared according to Example 1, the reaction mixture was heated to 90° C. during 1 hour and maintained at 90° C. for 2 hours. After cooling down to room temperature 200 ml of ice-water were added to the reaction mixture, the pH value was adjusted to 1 by adding concentrated hydrochloric acid and the mixture was let stand at 5° C. for 16 hours. After filtration the precipitate was washed 3 times on the filter and dried at 40° C. under reduced pressure.

Aufarbeitung

  1. customprepared
  2. temperaturemaintained at 90° C. for 2 hours
  3. additionwere added to the reaction mixture
  4. customat 5° C.
  5. customfor 16 hours
  6. filtrationAfter filtration the precipitate
  7. washwas washed 3 times on the
  8. filtrationfilter
  9. customdried at 40° C. under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-14a88a091db240c3ae7f0ae0f07a0afd
Quelldatensatz
uspto-grants-1995_05
Patentnummer
US05414108

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