Acetic Acid → HCID 23293235, Verbindung

HRID 365954

Reaktionsgleichung

Reaktionsgleichung von HRID 365954
[Br:1]Br.C(O)(=O)C.[CH3:7][C:8]1[C:13]([C:14]([O:16][CH2:17][CH3:18])=[O:15])=[C:12]([OH:19])[CH:11]=[CH:10][CH:9]=1>O.C(OCC)(=O)C>[Br:1][C:9]1[CH:10]=[CH:11][C:12]([OH:19])=[C:13]([C:8]=1[CH3:7])[C:14]([O:16][CH2:17][CH3:18])=[O:15]

Komponenten

6

Edukt 3

HCID 176Acetic Acid2×HCID 24408BromineHCID 584222Ethyl 2-hydroxy-6-methylbenzoate

Produkt 1

HCID 23293235HCID 23293235, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

A mixture of bromine (5.05 ml, 0.099 mol) and acetic acid (15 ml) is added to a mixture of ethyl 6-methyl-2-hydroxybenzoate (17.05 g, 0.095 mol), and acetic acid (15 ml) at a temperature of 20° C. The reaction mixture is stirred at room temperature for 1 hour. The reaction mixture is diluted with water and ethyl acetate. The organic phase is washed with water twice, concentrated in vacuo and the residue is purified by flash chromatography (petrol ethers:ethyl acetate, 98:2 v/v) yielding the pure product as a yellow oil, 21.7 g, (88.2%).

Aufarbeitung

  1. washThe organic phase is washed with water twice
  2. concentrationconcentrated in vacuo
  3. customthe residue is purified by flash chromatography (petrol ethers:ethyl acetate, 98:2 v/v)

Quellen und Nachweise

ORD-Eintrag
ord-a7b02d0bff1d45a7a3200b6dadfc077f
Quelldatensatz
uspto-grants-2000_10
Patentnummer
US06127570

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