Water → 1,4-Bisacetylamino-2-fluorobenzene

HRID 373443Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 373443
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:11])[CH3:10])=[C:4]([F:12])[CH:3]=1.O.[C:14](OC(=O)C)(=[O:16])[CH3:15]>C(O)(=O)C>[C:9]([NH:8][C:5]1[CH:6]=[CH:7][C:2]([NH:1][C:14](=[O:16])[CH3:15])=[CH:3][C:4]=1[F:12])(=[O:11])[CH3:10]

Komponenten

5

Edukt 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 255648n-(4-Amino-2-fluorophenyl)acetamide

Produkt 1

HCID 148170801,4-Bisacetylamino-2-fluorobenzene

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Reaktionsbedingungen

Temperatur
15 °C

Versuchsvorschrift

134.5 g (0.8 mol) of the 1-amino-4-acetylamino-3-fluorobenzene prepared above under A. are heated at 85° C. together with 800 ml of water and 34 g of acetic acid. 86.5 g of acetic anhydride are added to this mixture in the course of one hour. The reaction mixture is subsequently stirred at the same temperature for a further hour and cooled to 15° C. The product which has precipitated is then filtered off, washed twice with 150 ml of water each time and dried.

Aufarbeitung

  1. customThe product which has precipitated
  2. filtrationis then filtered off
  3. washwashed twice with 150 ml of water each time
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-af46820c16b94459930855801c4df6e6
Quelldatensatz
uspto-grants-1992_11
Patentnummer
US05163970

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