Formic Acid → 1-(6-Bromopyridin-2-yl)-2-morpholin-4-ylethanol

HRID 385797Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 385797
[Br:1][C:2]1[N:7]=[C:6]([C:8](=[O:16])[CH2:9][N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)[CH:5]=[CH:4][CH:3]=1.[BH4-].[Na+].C(O)=O>CO.C(OCC)(=O)C.C(=O)(O)[O-].[Na+].O>[Br:1][C:2]1[N:7]=[C:6]([CH:8]([OH:16])[CH2:9][N:10]2[CH2:11][CH2:12][O:13][CH2:14][CH2:15]2)[CH:5]=[CH:4][CH:3]=1

Komponenten

8

Edukt 3

HCID 284Formic AcidHCID 4311764Sodium borohydrideHCID 595263201-(6-Bromopyridin-2-yl)-2-morpholin-4-ylethanone

Produkt 1

HCID 595260601-(6-Bromopyridin-2-yl)-2-morpholin-4-ylethanol

Reagenzien, Katalysatoren, Lösungsmittel 4

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittelHCID 8857Ethyl AcetateLösungsmittelHCID 516892Sodium BicarbonateLösungsmittel

Versuchsvorschrift

To a solution of 1-(6-bromopyridin-2-yl)-2-morpholin-4-ylethanone (234 mg, 0.82 mmol) in methanol at 0° C. was added sodium borohydride (31.0 mg, 0.82 mmol). After 30 minutes, formic acid (0.1 mL) was added and then the reaction mixture was diluted with ethyl acetate (40 mL), saturated aqueous sodium bicarbonate (10 mL), and water (10 mL). The layers were separated and the organic layer was washed with brine (10 mL), dried over sodium sulfate, filtered, and concentrated to give the title compound.

Aufarbeitung

  1. customThe layers were separated
  2. washthe organic layer was washed with brine (10 mL)
  3. dry with materialdried over sodium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-c55cd15ae1fc47f487154705eca98c17
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08367706B2

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