Hydroxyamine hydrochloride → 4-Fluoro-naphthalene-1-carbaldehyde oxime

HRID 388375Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 388375
C([O-])(=O)C.[Na+].Cl.[NH2:7][OH:8].[F:9][C:10]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[C:13]([CH:20]=O)=[CH:12][CH:11]=1>C1COCC1.O>[F:9][C:10]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[C:13]([CH:20]=[N:7][OH:8])=[CH:12][CH:11]=1

Komponenten

6

Edukt 3

HCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 70225244-Fluoronaphthalene-1-carbaldehyde

Produkt 1

HCID 866581594-Fluoro-naphthalene-1-carbaldehyde oxime

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Sodium acetate (4.8 g) is added to a solution of hydroxylamine hydrochloride (2.9 g) and 4-fluoro-naphthalene-1-carbaldehyde (8.1 g, example 1 step B) in THF (40 ml) and water (10 ml). After 3 hours at room temperature, the reaction is quenched with water and ethyl acetate. The organic, phase is separated and the water phase is extracted with ethyl acetate. The combined organic phases are washed with water and with a saturated aqueous solution of NaCl, dried over Mg2SO4 and concentrated in vacuo to yield 4-fluoro-naphthalene-1-carbaldehyde oxime. The crude product obtained is used without further purification.

Aufarbeitung

  1. customthe reaction is quenched with water and ethyl acetate
  2. customThe organic, phase is separated
  3. extractionthe water phase is extracted with ethyl acetate
  4. washThe combined organic phases are washed with water and with a saturated aqueous solution of NaCl
  5. dry with materialdried over Mg2SO4
  6. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-3b266ea26e3643ad97a7c9fef3778853
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08377942B2

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