Ethanone, 1-(2,4,6-trimethylphenyl)- → 2-Bromo-1-mesitylethanone

HRID 399621

Reaktionsgleichung

Reaktionsgleichung von HRID 399621
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([CH3:9])[C:3]=1[C:10](=[O:12])[CH3:11].[Br:13]Br>C(O)(=O)C>[Br:13][CH2:11][C:10]([C:3]1[C:4]([CH3:9])=[CH:5][C:6]([CH3:8])=[CH:7][C:2]=1[CH3:1])=[O:12]

Komponenten

4

Edukt 2

HCID 15461Ethanone, 1-(2,4,6-trimethylphenyl)-HCID 24408Bromine

Produkt 1

HCID 2194802-Bromo-1-mesitylethanone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

0.3 mol of 1-(2,4,6-trimethylphenyl)-1-ethanone are dissolved in 200 ml of glacial acetic acid and 31.8 g of bromine are added dropwise, while maintaining the reaction medium at a temperature below 10° C. After the addition, the reaction medium is allowed to return to room temperature and is left at this temperature for 2 hours. The reaction medium is then poured into 500 ml of ice-water and the aqueous phase is extracted with ethyl ether. The organic extracts are washed with saturated aqueous sodium bicarbonate solution and then with salted water, and are dried over anhydrous magnesium sulphate.

Aufarbeitung

  1. temperaturewhile maintaining the reaction medium at a temperature below 10° C
  2. additionAfter the addition
  3. customto return to room temperature
  4. extractionthe aqueous phase is extracted with ethyl ether
  5. washThe organic extracts are washed with saturated aqueous sodium bicarbonate solution
  6. dry with materialwith salted water, and are dried over anhydrous magnesium sulphate

Quellen und Nachweise

ORD-Eintrag
ord-353412e3c05141c8a58340eb1f889fcc
Quelldatensatz
uspto-grants-1998_10
Patentnummer
US05821255

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