Cesium carbonate → (S)-6-tert-Butyl-8-fluoro-2-(3-(hydroxymethyl)-4-(5-(5-(2-methyl-4-(oxetan-3-yl)piperazin-1-yl)pyridin-2-ylamino)-6-oxo-1,6-dihydropyridin-3-yl)pyridin-2-yl) phthalazin-1(2H)-one

Reaktionsgleichung

Cl[C:2]1[CH:3]=[C:4]([NH:9][C:10]2[CH:15]=[CH:14][C:13]([N:16]3[CH2:21][CH2:20][N:19]([CH:22]4[CH2:25][O:24][CH2:23]4)[CH2:18][C@@H:17]3[CH3:26])=[CH:12][N:11]=2)[C:5](=[O:8])[NH:6][CH:7]=1.C([O:30][CH2:31][C:32]1[C:33]([N:47]2[N:56]=[CH:55][C:54]3[C:49](=[C:50]([F:61])[CH:51]=[C:52]([C:57]([CH3:60])([CH3:59])[CH3:58])[CH:53]=3)[C:48]2=[O:62])=[N:34][CH:35]=[CH:36][C:37]=1B1OC(C)(C)C(C)(C)O1)(=O)C.C1CCC(P(C2CCCCC2)C2CCCCC2)CC1.C([O-])([O-])=O.[Cs+].[Cs+]>C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd].O.O1CCOCC1>[C:57]([C:52]1[CH:53]=[C:54]2[C:49](=[C:50]([F:61])[CH:51]=1)[C:48](=[O:62])[N:47]([C:33]1[C:32]([CH2:31][OH:30])=[C:37]([C:2]3[CH:3]=[C:4]([NH:9][C:10]4[CH:15]=[CH:14][C:13]([N:16]5[CH2:21][CH2:20][N:19]([CH:22]6[CH2:25][O:24][CH2:23]6)[CH2:18][C@@H:17]5[CH3:26])=[CH:12][N:11]=4)[C:5](=[O:8])[NH:6][CH:7]=3)[CH:36]=[CH:35][N:34]=1)[N:56]=[CH:55]2)([CH3:60])([CH3:58])[CH3:59]