HCID 11594031, Verbindung → 2-(5-Hydroxy-pyridin-2-yl)-chromen-4-one

HRID 418851Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 418851
C[O:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[O:10][C:11]3[C:16]([C:17](=[O:19])[CH:18]=2)=[CH:15][CH:14]=[CH:13][CH:12]=3)=[N:7][CH:8]=1>I.CC(O)=O.O>[OH:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[O:10][C:11]3[C:16]([C:17](=[O:19])[CH:18]=2)=[CH:15][CH:14]=[CH:13][CH:12]=3)=[N:7][CH:8]=1

Komponenten

5

Edukt 1

HCID 11594031HCID 11594031, Verbindung

Produkt 1

HCID 116731392-(5-Hydroxy-pyridin-2-yl)-chromen-4-oneAusbeute 36,2 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 176Acetic AcidLösungsmittelHCID 962WaterLösungsmittelHCID 24841Hydrogen iodideLösungsmittel

Versuchsvorschrift

2-(5-Methoxy-pyridin-2-yl)-chromen-4-one (790 mg, 3.12 mmol) in HI (10 mL) and AcOH (4 mL) was heated at reflux for 6 h. Reaction mixture was cooled to rt, diluted with water, neutralized and extracted with EtOAc to give crude product. This was purified by column chromatography using 5% MeOH in dichloromethane to give (270 mg, 36%) of 2-(5-Hydroxy-pyridin-2-yl)-chromen-4-one. MS (ES) m/z: 240.09 (M+1).

Aufarbeitung

  1. temperatureat reflux for 6 h
  2. customReaction mixture
  3. extractionextracted with EtOAc
  4. customto give crude product
  5. customThis was purified by column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-127ba3a49332412d9999179cde4729fa
Quelldatensatz
uspto-grants-2012_01
Patentnummer
US08093273B2

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