Water → 2-(2-Iodo-5-methoxyphenyl)acetic acid

HRID 4280

Reaktionsgleichung

Reaktionsgleichung von HRID 4280
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:9][C:10]([OH:12])=[O:11])[CH:6]=[CH:7][CH:8]=1.[I:13]Cl.O>C(O)(=O)C.II>[I:13][C:6]1[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][C:5]=1[CH2:9][C:10]([OH:12])=[O:11]

Komponenten

6

Edukt 3

HCID 962WaterHCID 15719(3-Methoxyphenyl)acetic acidHCID 24640Iodine chloride

Produkt 1

HCID 8200712-(2-Iodo-5-methoxyphenyl)acetic acidAusbeute 65 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 807IodineKatalysatorHCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

A solution of 45 g (0.27 mole) of 3-methoxybenzeneacetic acid, 52.6 g (0.32 mole) of iodine monochloride and 1 g of iodine was allowed to stand in 500 ml of glacial acetic acid for six days at room temperature. The reaction was poured into water and the solid collected. It was recrystallized from toluene to give 51 g of crystalline 2-iodo-5-methoxybenzeneacetic acid, mp 133.5°-134.5° C. (65% yield).

Aufarbeitung

  1. customthe solid collected
  2. customIt was recrystallized from toluene

Quellen und Nachweise

ORD-Eintrag
ord-06fbe5b3f1e34d95a302135ea4df5b48
Quelldatensatz
uspto-grants-1988_02
Patentnummer
US04725602

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