Water → HCID 21942407, Verbindung

HRID 431873

Reaktionsgleichung

Reaktionsgleichung von HRID 431873
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[O:11][C:12]([F:15])([F:14])[F:13].[Br:16]Br.O>C(O)(=O)C>[NH2:1][C:2]1[C:3]([O:11][C:12]([F:13])([F:14])[F:15])=[CH:4][C:5]([C:6]([OH:8])=[O:7])=[CH:9][C:10]=1[Br:16]

Komponenten

5

Edukt 3

HCID 962WaterHCID 24408BromineHCID 27359514-amino-3-(trifluoromethoxy)benzoic Acid

Produkt 1

HCID 21942407HCID 21942407, VerbindungAusbeute 57,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel2×

Versuchsvorschrift

To a solution of 4-amino-3-trifluoromethoxybenzoic acid (5 g, 22.6 mmoles) in acetic acid (50 mL), bromine(3.98 g, 24.9 mmoles) in acetic acid(10 mL) was added dropwise at room temperature. After the reaction mixture was kept stirring for one hour, water was added into the mixture. The solid was filtered and washed with water to give 4-amino-3-bromo-5-trifluoromethoxybenzoic acid (3.9 g, 54.9%).

Aufarbeitung

  1. filtrationThe solid was filtered
  2. washwashed with water

Quellen und Nachweise

ORD-Eintrag
ord-2ca0e522c37f40aeba58016934a2063d
Quelldatensatz
uspto-grants-2003_12
Patentnummer
US06660753B2

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