Formic Acid → N-(3-(dimethylamino)propyl)formamide

HRID 435923

Reaktionsgleichung

Reaktionsgleichung von HRID 435923
[CH:1]([OH:3])=O.[CH3:4][N:5]([CH2:7][CH2:8][CH2:9][NH2:10])[CH3:6].C1(C)C=CC=CC=1>O>[CH3:4][N:5]([CH3:6])[CH2:7][CH2:8][CH2:9][NH:10][CH:1]=[O:3]

Komponenten

5

Edukt 3

HCID 284Formic AcidHCID 1140TolueneHCID 7993N,N-Dimethyl-1,3-propanediamine

Produkt 1

HCID 80020N-(3-(dimethylamino)propyl)formamideAusbeute 59 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel2×

Versuchsvorschrift

Formic acid (23 g., 0.5 mole), dimethylaminopropylamine (51 g., 0.5 mole) and toluene (50 ml) were azeotroped together with continual removal of water using a Dean and Stark separator until no more water was formed. Toluene was distilled off and the pale yellow residue distilled in vacuo. The colourless liquid product of low smell (N-(3-dimethylaminopropyl)formamide) was obtained in a yield of 59% of theory, b.p. 140° C/15 mm Hg.

Aufarbeitung

  1. customwas formed
  2. distillationToluene was distilled off
  3. distillationthe pale yellow residue distilled in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-e537d7b8b53e40359f2afc800bf1e2f2
Quelldatensatz
uspto-grants-1977_02
Patentnummer
US04007140

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