2-Methyl-4-nitroaniline → Acetamide, N-(2-methyl-4-nitrophenyl)-

HRID 436543

Reaktionsgleichung

Reaktionsgleichung von HRID 436543
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[CH3:11].[C:12](OC(=O)C)(=[O:14])[CH3:13]>O1CCCC1.C(O)(=O)C>[NH:1]([C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[CH3:11])[C:12]([CH3:13])=[O:14]

Komponenten

5

Edukt 2

HCID 74412-Methyl-4-nitroanilineHCID 7918Acetic Anhydride

Produkt 1

HCID 75936Acetamide, N-(2-methyl-4-nitrophenyl)-

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 176Acetic AcidLösungsmittel2×HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

349.6g (2.3 moles) of 4-amino-3-methyl-nitrobenzene were dissolved in 500g of tetrahydrofuran, 500g of acetic acid were added thereto, and 500g (3.5 moles) of acetic anhydride were added dropwise while stirring and heating at 70° to 80° C, and, after the completion of the acetic acid addition, the entire reaction system was reacted for 1 hour under reflux and then was allowed to cool whereby crystals were formed. The crystals were separated, filtered out and then dried.

Aufarbeitung

  1. additionwere added
  2. temperatureheating at 70° to 80° C
  3. customthe entire reaction system was reacted for 1 hour
  4. temperatureunder reflux
  5. temperatureto cool whereby crystals
  6. customwere formed
  7. customThe crystals were separated
  8. filtrationfiltered out
  9. customdried

Quellen und Nachweise

ORD-Eintrag
ord-e8f415aedd1a4dbf882e872f0137502f
Quelldatensatz
uspto-grants-1977_02
Patentnummer
US04009205

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