Cystamine Dihydrochloride → HCID 21453017, Verbindung

HRID 436649

Reaktionsgleichung

Reaktionsgleichung von HRID 436649
[F:1][C:2]([F:14])([F:13])[O:3][C:4]1[CH:12]=[CH:11][C:7]([C:8](Cl)=[O:9])=[CH:6][CH:5]=1.Cl.Cl.[NH2:17][CH2:18][CH2:19][S:20][S:21][CH2:22][CH2:23][NH2:24].[OH-:25].[Na+]>C(Cl)CCl>[CH2:19]([S:20][S:21][CH2:22][CH2:23][NH:24][C:8](=[O:9])[C:7]1[CH:11]=[CH:12][C:4]([O:25][C:2]([F:1])([F:13])[F:14])=[CH:5][CH:6]=1)[CH2:18][NH:17][C:8](=[O:9])[C:7]1[CH:11]=[CH:12][C:4]([O:3][C:2]([F:14])([F:13])[F:1])=[CH:5][CH:6]=1

Komponenten

5

Edukt 3

HCID 5941Cystamine DihydrochlorideHCID 14798Sodium HydroxideHCID 1421104-(Trifluoromethoxy)benzoyl Chloride

Produkt 1

HCID 21453017HCID 21453017, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 111,2-DichloroethaneLösungsmittel

Versuchsvorschrift

m.p. 150°-151° C., 14.5 g., was prepared as in Example 1 using 33.6 g. of 4-trifluoromethoxybenzoyl chloride in 100 ml. of ethylene dichloride, 11.3 g. of cystamine dihydrochloride, 300 ml. of 10% sodium hydroxide solution, 400 ml. of ethylene dichloride and recrystallization from acetonitrile using decolorizing charcoal.

Aufarbeitung

  1. custom, was prepared as in Example 1 using 33.6 g
  2. customof ethylene dichloride and recrystallization from acetonitrile using

Quellen und Nachweise

ORD-Eintrag
ord-6f459ac2cfe64807a84e0880839d34fc
Quelldatensatz
uspto-grants-1977_02
Patentnummer
US04009208

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