3,4-Dimethylbenzaldehyde → Biphenyl

HRID 438087

Reaktionsgleichung

Reaktionsgleichung von HRID 438087
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4.Cc1ccc(C=O)cc1C>CC(=O)N(C)C.CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)[O-].CC(C)[O-].CC(C)[O-].CC(C)[O-].[Na+].[Ti+4]>CO[C@@H]1[C@H](N(C)Cc2ccc(C)c(C)c2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4

Komponenten

10

Edukt 2

HCID 222783,4-DimethylbenzaldehydeHCID 44259Staurosporine

Produkt 4

HCID 7095BiphenylHCID 234073,4-Dimethylbenzyl alcoholHCID 44259StaurosporineHCID 178496676HCID 178496676, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 4

HCID 176Acetic AcidReagenzHCID 11026Titanium isopropoxideReagenzHCID 5049666Sodium triacetoxyborohydrideReagenzHCID 31374DimethylacetamideLösungsmittel7×

Reaktionsbedingungen

Temperatur
22 °C

Aufarbeitung

  1. additionThe next morning, the Mosquito(R) was used to dilute the 100 mM reactions to 50 mM via addition of 1 uL DMSO to each reaction well, followed by dispense mixing.
  2. additionThe reactions were diluted with 3x1 uL DMSO (containing PhPh as an internal standard) using the Mosquito(R). The reactions were mixed after each dispense operation.
  3. aliquotMosquito(R) was used to transfer 1 uL of each quenched reaction from the 1,536-well reaction plate to 384-well analytical plates containing 60 uL DMSO for analysis by UPLC.
  4. additionMosquito(R) was used to transfer 1 uL of each quenched reaction from the 1,536-well reaction plate to 384-well analytical plates containing 60 uL DMSO for analysis by UPLC.

Quellen und Nachweise

ORD-Eintrag
ord-f3d2bfb14bae4a5f95e159abf471d503
Quelldatensatz
Cernak miniaturized reductive amination
Originallink
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