Sodium Carbonate → Ethyl 3-amino-6-bromo-5-(trifluoromethyl)pyrazine-2-carboxylate

HRID 444925Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 444925
[CH2:1]([O:3][C:4]([C:6]1[C:11]([NH2:12])=[N:10][C:9]([C:13]([F:16])([F:15])[F:14])=[CH:8][N:7]=1)=[O:5])[CH3:2].C(=O)([O-])[O-].[Na+].[Na+].[Br:23]Br>C(O)(=O)C.O>[CH2:1]([O:3][C:4]([C:6]1[C:11]([NH2:12])=[N:10][C:9]([C:13]([F:15])([F:16])[F:14])=[C:8]([Br:23])[N:7]=1)=[O:5])[CH3:2]

Komponenten

6

Edukt 3

HCID 10340Sodium Carbonate2×HCID 24408Bromine2×HCID 58442356HCID 58442356, Verbindung2×

Produkt 1

HCID 72942096Ethyl 3-amino-6-bromo-5-(trifluoromethyl)pyrazine-2-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 176Acetic AcidLösungsmittel3×HCID 962WaterLösungsmittel

Versuchsvorschrift

To a solution of 3-amino-5-trifluoromethyl-pyrazine-2-carboxylic acid ethyl ester (Intermediate B) (30 mg, 0.13 mmol) in acetic acid (5 ml), sodium carbonate (15 mg, 0.14 mmol) was added. To this mixture, half the contents of a solution of bromine (7 μL, 0.13 mmol) in acetic acid (5 ml) were added, followed by the addition of sodium carbonate ((15 mg, 0.14 mmol). The remaining solution of bromine in acetic acid was added and the reaction mixture was left to stir at RT for 2 hours. The mixture was diluted with water and the resulting yellow precipitate was filtered under vacuum to afford the title compound.

Aufarbeitung

  1. waitthe reaction mixture was left
  2. filtrationthe resulting yellow precipitate was filtered under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-57bbf8d64c19419682090e593262ed0c
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08476269B2

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