Acetic Acid → Orotic Acid

HRID 461647

Reaktionsgleichung

Cl[C:2](Cl)(Cl)[C:3](Cl)=[O:4].ClC(Cl)(Cl)C(=O)CC(Cl)=O.[NH2:18][C:19]([NH2:21])=[O:20].[C:22]([OH:25])(=[O:24])[CH3:23]>>[C:22]([OH:25])(=[O:24])[C:23]1[NH:21][C:19](=[O:20])[NH:18][C:3](=[O:4])[CH:2]=1

Komponenten

Edukt 4

HCID 176Acetic Acid

HCID 1176Urea

HCID 6420Trichloroacetyl chloride

HCID 213917244,4,4-Trichloro-3-oxobutanoyl chloride

Produkt 1

HCID 967Orotic Acid

Versuchsvorschrift

To recap, this invention involves: converting trichloroacetyl chloride with ketone to γ,γ ,γ -trichloroacetoacetyl chloride, adding the reaction mixture to urea dissolved in a polar organic solvent, e.g., acetic acid; evaporating out the resulting 6-trichloromethyluracil; and hydrolyzing the 6-trichloromethyluracil to form orotic acid.

Aufarbeitung

customevaporating out the resulting 6-trichloromethyluracil

Quellen und Nachweise

ORD-Eintrag: ord-3be252f833cc47e5a14f6bf37e6b0113
Quelldatensatz: uspto-grants-1977_12
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US04064126

Verknüpfte Notizen

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