Phthalic Acid → 2-(1H-Indazol-3-yl)-1H-isoindole-1,3(2H)-dione

HRID 464817Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 464817
[NH2:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[NH:4][N:3]=1.[C:11](O)(=[O:21])[C:12]1[C:13](=[CH:17][CH:18]=[CH:19][CH:20]=1)[C:14](O)=[O:15].C(OCC)C>O>[C:11]1(=[O:21])[N:1]([C:2]2[C:10]3[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=3)[NH:4][N:3]=2)[C:14](=[O:15])[C:13]2=[CH:17][CH:18]=[CH:19][CH:20]=[C:12]12

Komponenten

5

Edukt 3

HCID 1017Phthalic AcidHCID 3283Diethyl EtherHCID 133991H-indazol-3-amine

Produkt 1

HCID 27558572-(1H-Indazol-3-yl)-1H-isoindole-1,3(2H)-dioneAusbeute 87 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
120 °C

Versuchsvorschrift

5.0 g of the same 3-aminoindazole as Example 1 and 6.68 g of phthalic acid were added to 50 ml of dixoane, and the mixture was stirred for 5 hours at 120° C. The mixture was condensed under reduced pressure, 30 ml of diethyl ether was added and the mixture was stirred under cooling with ice and water for 30 minutes to separate crystals. The crystals were obtained by filtration and dried under reduced pressure to give 8.6 g of 3-phthalimidoindazole in a yield of 87%.

Aufarbeitung

  1. additionwas added
  2. stirringthe mixture was stirred
  3. customto separate crystals
  4. customThe crystals were obtained by filtration
  5. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-02efb5e9fcbc4826999ed255b3ec1c4c
Quelldatensatz
uspto-grants-1985_10
Patentnummer
US04549023

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