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Methanol → Diphenylmethyl 7beta-Amino-3-(2,5-dihydro-2-oxofuran-4-ylmethyloxy)ceph-3-em-4-carboxylate

HRID 467382
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 467382
[O:1]=[C:2]1[CH:6]=[C:5]([CH2:7][O:8][C:9]2[CH2:10][S:11][C@@H:12]3[C@H:32]([NH:33]C(=O)CC4C=CC=CC=4)[C:31](=[O:43])[N:13]3[C:14]=2[C:15]([O:17][CH:18]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[O:16])[CH2:4][O:3]1.CN1CCOCC1.P(Cl)(Cl)(Cl)(Cl)Cl.CO>ClCCl.O>[NH2:33][C@@H:32]1[C:31](=[O:43])[N:13]2[C:14]([C:15]([O:17][CH:18]([C:25]3[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=3)[C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)=[O:16])=[C:9]([O:8][CH2:7][C:5]3[CH2:4][O:3][C:2](=[O:1])[CH:6]=3)[CH2:10][S:11][C@H:12]12
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Komponenten

7

Edukt 4

HCID 887MethanolHCID 79724-MethylmorpholineHCID 24819Phosphorus pentachlorideHCID 67908619Diphenylmethyl 3-(2,5-dihydro-2-oxofuran-4-ylmethyl oxy)-7beta-phenylacetamidoceph-3-em-4-carboxylate

Produkt 1

HCID 67908486Diphenylmethyl 7beta-Amino-3-(2,5-dihydro-2-oxofuran-4-ylmethyloxy)ceph-3-em-4-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 6344DichloromethaneLösungsmittel2×

Reaktionsbedingungen

Temperatur
-20 °C

Versuchsvorschrift

Diphenylmethyl 3-(2,5-dihydro-2-oxofuran-4-ylmethyl oxy)-7β-phenylacetamidoceph-3-em-4-carboxylate (958 mg) was dissolved in dichloromethane (13 ml) whilst under an inert atmosphere. The solution was cooled to -20° C. before treating with N-methylmorpholine (352 μl) followed by a solution of phosphorous pentachloride in dichloromethane (12.5 ml of 40 mg ml-1 solution). After stirring for 30 min. at -20° C. the solution was treated with methanol (3.2 ml) and then allowed to warm to RT. After a further 30 min. water (4.3 ml) was added and the reaction was stirred vigorously for 60 min. Solvent was removed by evaporation in vacuo and the residue dissolved in ethyl acetate/water. The pH of the mixture was adjusted to 6.5 with 1.0M aqueous ammonia. Separation of the organic phase was followed by washing with water and brine before drying over anhydrous magnesium sulphate. Purification was accomplished by chromatography of the crude material on silica gel (Keiselgel) eluting with ethyl acetate. The title compound was finally isolated as a foam (565 mg). υmax (CH2Cl2) 1780, 1755 and 1730cm-1 ; δH(CDCl3) 3.34 (1H, d, J 17.7Hz), 3.54 (1H, d, J 17.7Hz), 4.51-4.58 (2H, m), 4.70 (2H, bs) 4.75 (1H, d, J 4.7Hz), 4.97 (1H, d, J 4.7Hz), 5.93 (1H, s), and 7.26-7.40 (10H, m). [Mass spectrum: FAB +ve ion (3NOBA/Na+) MNa+ 501].

Aufarbeitung

  1. temperatureto warm to RT
  2. stirringthe reaction was stirred vigorously for 60 min
  3. customSolvent was removed by evaporation in vacuo
  4. dissolutionthe residue dissolved in ethyl acetate/water
  5. customSeparation of the organic phase
  6. washby washing with water and brine
  7. dry with materialbefore drying over anhydrous magnesium sulphate
  8. customPurification
  9. washeluting with ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-db98e1379050445c8ec20cda286c1ad9
Quelldatensatz
uspto-grants-1992_10
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US05158946

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