Diisopropylamine → 1,1'-Dodecane-1,12-diyldicyclopropane carbonitrile

Temperatur

-20 °C

A solution of n-butyl lithium in hexane (1.8M, 1.06 L, 1.92 mol) was added drop wise to a solution of freshly distilled diisopropylamine (280.8 mL, 1.82 mol) in dry THF (1.5 L) at −60° C. under nitrogen atmosphere. The reaction mixture was slowly warmed to −20° C. and stirred for 30 min. The reaction mixture was re-cooled to −78° C., DMPU (29.3 g, 0.22 mol) was added drop wise and stirred for 15 min. Then cyclopropane carbonitrile (122.7 g, 1.82 mol) added drop wise over a period 1 h and stirred for 1 h. To the reaction mixture was added drop wise 1,12-dibromododecane (150.0 g, 0.45 mol) in dry THF (150 mL) and continued stirring at −78° C. for 2 h. The reaction mixture was slowly allowed to reach room temperature and continued stirring over a period of 16 h. The resulting reaction mixture was quenched with saturated NH4Cl (3.0 L) at 0° C. and the reaction mixture was extracted with ethyl acetate (1 L×3). The organic phases were combined, dried over anhydrous Na2SO4 and volatiles were evaporated under reduced pressure to yield a pale yellow liquid which was purified through silica gel (230-400) column (5% ethyl acetate in petroleum ether) to give product as off-white solid. The off-white solid washed with petroleum ether to obtain product as white solid 112 g (81.5%). mp: 45.0° C.-46.9° C.

1. temperatureThe reaction mixture was re-cooled to −78° C.
2. stirringstirred for 15 min
3. stirringstirred for 1 h
4. stirringcontinued stirring at −78° C. for 2 h
5. customto reach room temperature
6. stirringcontinued stirring over a period of 16 h
7. customThe resulting reaction mixture
8. customwas quenched with saturated NH4Cl (3.0 L) at 0° C.
9. extractionthe reaction mixture was extracted with ethyl acetate (1 L×3)
10. dry with materialdried over anhydrous Na2SO4 and volatiles
11. customwere evaporated under reduced pressure
12. customto yield a pale yellow liquid which
13. customwas purified through silica gel (230-400) column (5% ethyl acetate in petroleum ether)
14. customto give product as off-white solid
15. washThe off-white solid washed with petroleum ether

ORD-Eintrag

ord-1288f2b84571425cb18f6bbc0a8dccc9

Quelldatensatz

uspto-grants-2014_01

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08623897B2