1-(3-Pyrrolidinopropyl)Piperazine → Ammonia

HRID 469131

Reaktionsgleichung

Reaktionsgleichung von HRID 469131
[CH:1]1([N:4]([CH2:18][C:19]2[S:23][C:22]([C:24]([O:26]CC)=O)=[N:21][N:20]=2)[S:5]([C:8]2[C:13]([CH3:14])=[CH:12][C:11]([O:15][CH3:16])=[CH:10][C:9]=2[CH3:17])(=[O:7])=[O:6])[CH2:3][CH2:2]1.[N:29]1([CH2:34][CH2:35][CH2:36][N:37]2[CH2:42][CH2:41][NH:40][CH2:39][CH2:38]2)[CH2:33][CH2:32][CH2:31][CH2:30]1.C[Al](C)C>ClCCCl>[NH3:4].[CH:1]1([N:4]([CH2:18][C:19]2[S:23][C:22]([C:24]([N:40]3[CH2:39][CH2:38][N:37]([CH2:36][CH2:35][CH2:34][N:29]4[CH2:30][CH2:31][CH2:32][CH2:33]4)[CH2:42][CH2:41]3)=[O:26])=[N:21][N:20]=2)[S:5]([C:8]2[C:13]([CH3:14])=[CH:12][C:11]([O:15][CH3:16])=[CH:10][C:9]=2[CH3:17])(=[O:7])=[O:6])[CH2:2][CH2:3]1

Komponenten

6

Edukt 3

HCID 27372521-(3-Pyrrolidinopropyl)PiperazineHCID 16682925TrimethylaluminumHCID 58393201HCID 58393201, Verbindung

Produkt 2

HCID 222AmmoniaHCID 46175283N-Cyclopropyl-4-methoxy-2,6-dimethyl-N-[(5-{[4-(3-pyrrolidin-1-ylpropyl)piperazin-1-yl]carbonyl}-1,3,4-thiadiazol-2-yl)methyl]benzenesulfonamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 111,2-DichloroethaneLösungsmittel

Versuchsvorschrift

The title compound was prepared according to general procedure AT using ethyl 5-({cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-1,3,4-thiadiazole-2-carboxylate (30 mg, 0.07 mmol), 1-[3-(pyrrolidin-1-yl)propyl]piperazine (31 mg, 0.16 mmol) and trimethylaluminium (2 M in toluene, 0.07 mL) in DCE (5 mL). The crude product was purified using FCC, eluting with 95:4.5:0.5 DCM:MeOH:NH3, to afford the title compound.

Aufarbeitung

  1. customThe title compound was prepared
  2. customThe crude product was purified
  3. washeluting with 95:4.5:0.5 DCM

Quellen und Nachweise

ORD-Eintrag
ord-ec1cecb01d1f434e9eead81ef7b69f0a
Quelldatensatz
uspto-grants-2014_01
Patentnummer
US08623859B2

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