Water → HCID 70938331, Verbindung

2′,6′-dimethyl-4′-(3-(methylsulfonyl)propoxy)-[1,1′-biphenyl]-3-carbaldehyde (1.0 g) synthesized according to a method described in [WO 2008/001931 pamphlet, (Reference Example 18)] and 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline (0.63 g) were dissolved in methylene chloride (10 mL), and to the resultant solution, sodium triacetoxyborohydride (1.84 g) was added, followed by stirring the resultant reaction mixture at room temperature for 14 hours. To the reaction mixture, water (20 mL) was added, followed by extracting the reaction mixture with methylene chloride (20 mL) twice, and the resultant organic phase was washed sequentially with water (50 mL) and a saturated saline (50 mL) and was dried over anhydrous sodium sulfate. From the organic phase, the solvent was distilled off under reduced pressure to obtain the subject compound (1.4 g) as a colorless amorphous solid.

1. customreaction mixture at room temperature for 14 hours
2. extractionby extracting the reaction mixture with methylene chloride (20 mL) twice
3. washthe resultant organic phase was washed sequentially with water (50 mL)
4. dry with materiala saturated saline (50 mL) and was dried over anhydrous sodium sulfate
5. distillationFrom the organic phase, the solvent was distilled off under reduced pressure

ORD-Eintrag

ord-2ca9857ca2db4a1d9ae9061987fac7fc

Quelldatensatz

uspto-grants-2014_01

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08629102B2