1,2-Dichloroethane → HCID 68078786, Verbindung

HRID 475966

Reaktionsgleichung

Reaktionsgleichung von HRID 475966
[CH:1]1([C:4]2[CH:5]=[C:6]([C:16]([OH:18])=O)[C:7]3[CH:12]=[N:11][N:10]([CH:13]([CH3:15])[CH3:14])[C:8]=3[N:9]=2)[CH2:3][CH2:2]1.Cl.[NH2:20][CH2:21][C:22]1[C:23](=[O:32])[NH:24][C:25]([CH:29]2[CH2:31][CH2:30]2)=[CH:26][C:27]=1[CH3:28].ON1C2N=CC=CC=2N=N1.C(Cl)CCl.CN1CCOCC1>O.CS(C)=O>[CH:1]1([C:4]2[CH:5]=[C:6]([C:16]([NH:20][CH2:21][C:22]3[C:23](=[O:32])[NH:24][C:25]([CH:29]4[CH2:30][CH2:31]4)=[CH:26][C:27]=3[CH3:28])=[O:18])[C:7]3[CH:12]=[N:11][N:10]([CH:13]([CH3:14])[CH3:15])[C:8]=3[N:9]=2)[CH2:2][CH2:3]1

Komponenten

8

Edukt 5

HCID 111,2-DichloroethaneHCID 79724-MethylmorpholineHCID 181649HOAtHCID 25259926-cyclopropyl-1-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acidHCID 67124164HCID 67124164, Verbindung

Produkt 1

HCID 68078786HCID 68078786, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 679Dimethyl SulfoxideLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

To a 4 mL solution of DMSO were sequentially added 6-cyclopropyl-1-(1-methylethyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid (0.11 g, 0.448 mmol), 3-(aminomethyl)-6-cyclopropyl-4-methyl-2(1H)-pyridinone hydrochloride (0.106 g, 0.493 mmol), 1-hydroxy-7-azabenzotriazole (0.073 g, 0.538 mmol), EDC (0.103 g, 0.538 mmol), and then N-methylmorpholine (0.197 mL, 1.79 mmol) via syringe. After stirring overnight at room temperature, the suspension was diluted with 50 mL of water and stirred for 15 min. After standing at room temperature for 15 min., the reaction mixture was filtered and the collected solid washed with additional water. The solid was then dried in a vacuum oven at 45° C. for 4 h. The product was obtained as 0.165 g (89%). LCMS E-S (M+H)=406.5. 1H NMR (400 MHz, DMSO-d6) δ ppm 0.76-0.82 (m, 2H), 0.91-0.98 (m, 2H), 1.03-1.12 (m, 4H), 1.46 (d, J=6.82 Hz, 6H), 1.74-1.84 (m, 1H), 2.19 (s, 3H), 2.21-2.31 (m, 1H), 4.34 (d, J=5.05 Hz, 2H), 5.05-5.18 (m, 1H), 5.73 (s, 1H), 7.42 (s, 1H), 8.21 (s, 1H), 8.72 (t, J=4.93 Hz, 1H), 11.61 (br. s., 1H).

Aufarbeitung

  1. stirringstirred for 15 min
  2. waitAfter standing at room temperature for 15 min.
  3. filtrationthe reaction mixture was filtered
  4. washthe collected solid washed with additional water
  5. customThe solid was then dried in a vacuum oven at 45° C. for 4 h
  6. customThe product was obtained as 0.165 g (89%)

Quellen und Nachweise

ORD-Eintrag
ord-da854bcbfe264545ab2f87d6b0d72485
Quelldatensatz
uspto-grants-2014_01
Patentnummer
US08637509B2

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