Water → N-(2,3-Dihydro-1H-inden-2-yl)acetamide

HRID 48397

Reaktionsgleichung

Reaktionsgleichung von HRID 48397
[NH2:1][CH:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3]1.[C:11](OC(=O)C)(=[O:13])[CH3:12].O>N1C=CC=CC=1>[C:11]([NH:1][CH:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3]1)(=[O:13])[CH3:12]

Komponenten

5

Edukt 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 763102-Aminoindane

Produkt 1

HCID 12452137N-(2,3-Dihydro-1H-inden-2-yl)acetamideAusbeute 71,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

2-aminoindan (6.0 g, 45 mmol) was dissolved in dry pyridine (7 ml), to which acetic anhydride (4.5 ml, 47.3 mmol) was added dropwise while cooling in ice water. After the reaction mixture was returned to room temperature and stirred for 20 minutes, water was added. The precipitate that deposited was filtered to obtain 2-acetamidoindan (5.6 g, 32 mmol).

Aufarbeitung

  1. additionwas added dropwise
  2. customwas returned to room temperature
  3. filtrationThe precipitate that deposited was filtered

Quellen und Nachweise

ORD-Eintrag
ord-98d057ea4c4f49e8bf8e66ae144e62ee
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06703421B1

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