Water → 2-Acetamido-5-bromopyridine

HRID 49719

Reaktionsgleichung

Reaktionsgleichung von HRID 49719
C(O[C:5](=[O:7])[CH3:6])(=O)C.[NH2:8][C:9]1[CH:14]=[CH:13][C:12]([Br:15])=[CH:11][N:10]=1.O>C(O)(=O)C>[Br:15][C:12]1[CH:13]=[CH:14][C:9]([NH:8][C:5](=[O:7])[CH3:6])=[N:10][CH:11]=1

Komponenten

5

Edukt 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 706222-Amino-5-bromopyridine

Produkt 1

HCID 2930972-Acetamido-5-bromopyridine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

Acetic anhydride (27.4 mL) was added to a stirred suspension of 2-amino-5-bromopyridine (10.0 g) in acetic acid (40 mL). The mixture was heated at reflux for 4 hours, then cooled to room temperature and then poured into water (200 mL). The resulting solid was collected, washed three times with water (300 ml) and then dried in vacuo at 70° C., affording the title compound as a white solid (10.9 g).

Aufarbeitung

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 4 hours
  3. customThe resulting solid was collected
  4. washwashed three times with water (300 ml)
  5. customdried in vacuo at 70° C.

Quellen und Nachweise

ORD-Eintrag
ord-a8376e32560e4ae2b4a581d3d9db980c
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06706738B2

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