1,4-Diacetylbenzene → 1-(4-Acetylphenyl)-2-bromo-1-ethanone

HRID 497213

Reaktionsgleichung

Reaktionsgleichung von HRID 497213
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10](=[O:12])[CH3:11])=[CH:6][CH:5]=1)(=[O:3])[CH3:2].[Br:13]Br>C(OCC)C.O.[Cl-].[Al+3].[Cl-].[Cl-]>[C:10]([C:7]1[CH:8]=[CH:9][C:4]([C:1](=[O:3])[CH2:2][Br:13])=[CH:5][CH:6]=1)(=[O:12])[CH3:11]

Komponenten

6

Edukt 2

HCID 138881,4-DiacetylbenzeneHCID 24408Bromine

Produkt 1

HCID 149132991-(4-Acetylphenyl)-2-bromo-1-ethanoneAusbeute 88,8 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 6451240Aluminum(III) ChlorideKatalysatorHCID 962WaterLösungsmittelHCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

To a stirred solution of 1,4-diacetylbenzene (5.3 g, 32.7 mmol), aluminum chloride (0.05 g, 0.38 mmol) in diethylether (50 ml) was added bromine (5.3 g, 32.7 mmol) dropwise over 20 minutes. The mixture was stirred for 30 minutes, and diluted with water. The whole was concentrated to remove diethylether, and the aqueous suspension was filtered to give 7.0 g of white solid. The compound was used for next reaction without purification.

Aufarbeitung

  1. concentrationThe whole was concentrated
  2. customto remove diethylether
  3. filtrationthe aqueous suspension was filtered

Quellen und Nachweise

ORD-Eintrag
ord-51c10d8c02a449f0b3274ef84328c10f
Quelldatensatz
uspto-grants-2005_09
Patentnummer
US06949536B2

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