Methanol → (R)-2-Hydroxy-1-morpholinopropan-1-one

HRID 505674

Reaktionsgleichung

[C:1]([O:6]C)(=O)[C@@H:2]([CH3:4])[OH:3].[NH:8]1[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1.C[O-].[Na+].CO>>[N:8]1([C:1](=[O:6])[C@H:2]([OH:3])[CH3:4])[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1

Komponenten

Edukt 4

HCID 887Methanol

HCID 8083Morpholine

HCID 637514(+)-Methyl lactate

HCID 10942334Sodium Methoxide

Produkt 1

HCID 14978393(R)-2-Hydroxy-1-morpholinopropan-1-one

Reaktionsbedingungen

Temperatur: 50 °C

Versuchsvorschrift

To (R)-methyl lactate (24.42 g, 0.23 mol) were added morphline (21.46 g, 0.25 mol) and sodium methoxide in methanol (14%, 9.04 g, 0.02 mol) and the mixture was stirred for 3 hours at 50° C. After removal of the solvent in vacuo, the residue was subjected to azeotropic distillation three times with toluene to give the subject compound (quant.).

Aufarbeitung

customAfter removal of the solvent in vacuo
distillationthe residue was subjected to azeotropic distillation three times with toluene
customto give the subject compound (quant.)

Quellen und Nachweise

ORD-Eintrag: ord-e707a0c4b0174d8e9cf946366f8c997f
Quelldatensatz: uspto-grants-2010_08
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07781479B2

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