Water → 6-Chloro-4-(3-(pyridine-2-yl)benzylamino)nicotinamide

HRID 513295

Reaktionsgleichung

Cl[C:2]1[C:7]([C:8]([NH2:10])=[O:9])=[CH:6][N:5]=[C:4]([Cl:11])[CH:3]=1.[N:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[C:18]1[CH:19]=[C:20]([CH2:24][NH2:25])[CH:21]=[CH:22][CH:23]=1.CCN(C(C)C)C(C)C.O>CN1C(=O)CCC1>[Cl:11][C:4]1[CH:3]=[C:2]([NH:25][CH2:24][C:20]2[CH:21]=[CH:22][CH:23]=[C:18]([C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][N:12]=3)[CH:19]=2)[C:7]([C:8]([NH2:10])=[O:9])=[CH:6][N:5]=1

Komponenten

Reaktionsbedingungen

Temperatur: 80 °C

Versuchsvorschrift

To a solution of 4,6-dichloronicotinamide (73 mg, 0.38 mmol) in NMP (0.75 mL) was added (3-(pyridine-2-yl)phenyl)methanamine (77 mg, 0.42 mmol) and DIPEA (0.22 mL, 1.33 mmol). After stirring at 80° C. for 15 h, the mixture was added water, the resulting precipitate was collected by filtration to give 6-chloro-4-(3-(pyridine-2-yl)benzylamino)nicotinamide (56 mg).

Aufarbeitung

filtrationthe resulting precipitate was collected by filtration

Quellen und Nachweise

ORD-Eintrag: ord-e91be3ccec2d491cb3757dd53ea73e35
Quelldatensatz: uspto-grants-2015_08
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US09102625B2

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