Water → 4-(1-(3-(Difluoromethyl)phenyl)-2,5-dioxo-1,2,3,4,5,6,7,8-octahydroquinazolin-4-yl)-benzonitrile

Reaktionsgleichung

Br[C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[C:17]3[C:16](=[O:18])[CH2:15][CH2:14][CH2:13][C:12]=3[N:11]([C:19]3[CH:24]=[CH:23][CH:22]=[C:21]([CH:25]([F:27])[F:26])[CH:20]=3)[C:10](=[O:28])[NH:9]2)=[CH:4][CH:3]=1.O.[CH3:30][N:31](C)C=O>[C-]#N.[Zn+2].[C-]#N.[Pd].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>[F:27][CH:25]([F:26])[C:21]1[CH:20]=[C:19]([N:11]2[C:12]3[CH2:13][CH2:14][CH2:15][C:16](=[O:18])[C:17]=3[CH:8]([C:5]3[CH:4]=[CH:3][C:2]([C:30]#[N:31])=[CH:7][CH:6]=3)[NH:9][C:10]2=[O:28])[CH:24]=[CH:23][CH:22]=1