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Acetyl chloride → N-[4-(2-Amino-2-methyl-propoxy)-3-(2-methyl-2H-pyrazol-3-yl)-phenyl]-4-trifluoromethyl-benzamide

HRID 521643
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Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 521643
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=O)=[CH:5][CH:4]=1.C(Cl)(=O)C(Cl)=O.[CH3:20][N:21]1[C:25]([C:26]2[CH:27]=[C:28]([CH:30]=[CH:31][C:32]=2[O:33][CH2:34][C:35]([CH3:40])([N+:37]([O-])=O)[CH3:36])[NH2:29])=[CH:24][CH:23]=[N:22]1.CCN(C(C)C)C(C)C.C(Cl)(=O)C>ClCCl.CO.[Zn].CN(C=O)C>[NH2:37][C:35]([CH3:40])([CH3:36])[CH2:34][O:33][C:32]1[CH:31]=[CH:30][C:28]([NH:29][C:7](=[O:9])[C:6]2[CH:5]=[CH:4][C:3]([C:2]([F:1])([F:13])[F:12])=[CH:11][CH:10]=2)=[CH:27][C:26]=1[C:25]1[N:21]([CH3:20])[N:22]=[CH:23][CH:24]=1
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Komponenten

10

Edukt 5

HCID 6367Acetyl chlorideHCID 99664-(Trifluoromethyl)benzoic acidHCID 65578Oxalyl chlorideHCID 81531DiisopropylethylamineHCID 672657453-(2-methyl-2H-pyrazol-3-yl)-4-(2-methyl-2-nitropropoxy)aniline

Produkt 1

HCID 57814661
N-[4-(2-Amino-2-methyl-propoxy)-3-(2-methyl-2H-pyrazol-3-yl)-phenyl]-4-trifluoromethyl-benzamide
Ausbeute 57,1 %

Reagenzien, Katalysatoren, Lösungsmittel 4

HCID 23994ZincKatalysatorHCID 887MethanolLösungsmittelHCID 6228DimethylformamideLösungsmittelHCID 6344DichloromethaneLösungsmittel3×

Versuchsvorschrift

DMF (10 μL) was added to a mixture of 4-trifluoromethylbenzoic acid (61 mg, 0.32 mmol) and oxalyl chloride (27 μL, 0.32 mmol) in dichloromethane (0.5 mL) and the mixture was stirred for 45 min at room temperature. The solution of the crude acid chloride was added to a solution of 3-(2-methyl-2H-pyrazol-3-yl)-4-(2-methyl-2-nitropropoxy)aniline (62 mg, 0.21 mmol) and DIEA (146 μL, 0.84 mmol) in dichloromethane (0.5 mL) and the mixture was stirred at room temperature. After 14 h, the mixture was diluted with dichloromethane, washed with 0.5M citric acid and saturated sodium bicarbonate, dried with sodium sulfate, filtered, and evaporated to dryness. The residue was suspended in methanol (1 mL) and acetylchloride (164 μL, 2.3 mmol) was added slowly. A clear solution was obtained. Zinc dust (150 mg, 2.3 mmol) was added, and the mixture was stirred at 55° C. After 2 h, the mixture was allowed to cool to room temperature, and diluted with methanol. The precipitate was removed by filtration and washed with methanol. The combined washings were evaporated to dryness. The residue was suspended in 1M HCl, the mixture was cooled on an ice bath, and made alkaline with ammonium hydroxide. The solution was extracted with ethyl acetate, and the extract was washed with brine, dried with sodium sulfate, filtered, and evaporated to dryness. The crude product was purified by RP-HPLC. The trifluoroacetate was partitioned between ethyl acetate and saturated sodium bicarbonate, the organic layer was washed with brine, dried with sodium sulfate, filtered, and evaporated to dryness to afford the free base (53 mg, 0.12 mmol, 57%). LCMS m/z (%)=433.3 (M+H 60.7%). 1H NMR (400 MHz, DMSO-d6) δ ppm 0.95 (s, 6H), 3.67 (s, 2H), 3.68 (s, 3H), 6.28 (d, J=1.77 Hz, 1H), 7.15 (d, J=9.09 Hz, 1H), 7.48 (d, J=1.77 Hz, 1H), 7.70 (d, J=2.53 Hz, 1H), 7.84 (dd, J=8.97, 2.65 Hz, 1H), 7.92 (d, J=8.34 Hz, 2H), 8.14 (d, J=8.08 Hz, 2H), 10.46 (s, 1H).

Aufarbeitung

  1. stirringthe mixture was stirred at room temperature
  2. waitAfter 14 h
  3. washwashed with 0.5M citric acid and saturated sodium bicarbonate
  4. dry with materialdried with sodium sulfate
  5. filtrationfiltered
  6. customevaporated to dryness
  7. customA clear solution was obtained
  8. stirringthe mixture was stirred at 55° C
  9. waitAfter 2 h
  10. temperatureto cool to room temperature
  11. customThe precipitate was removed by filtration
  12. washwashed with methanol
  13. customThe combined washings were evaporated to dryness
  14. temperaturethe mixture was cooled on an ice bath
  15. extractionThe solution was extracted with ethyl acetate
  16. washthe extract was washed with brine
  17. dry with materialdried with sodium sulfate
  18. filtrationfiltered
  19. customevaporated to dryness
  20. customThe crude product was purified by RP-HPLC
  21. customThe trifluoroacetate was partitioned between ethyl acetate and saturated sodium bicarbonate
  22. washthe organic layer was washed with brine
  23. dry with materialdried with sodium sulfate
  24. filtrationfiltered
  25. customevaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-a69e79be79d7455fb0f64bb09de2dfca
Quelldatensatz
uspto-grants-2016_05
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US09328107B2

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