1,5-Dibromopentane → 1-[2-[(5-Bromopentyl)oxy]ethyl]-4-fluorobenzene

HRID 5218

Reaktionsgleichung

Reaktionsgleichung von HRID 5218
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][OH:10])=[CH:4][CH:3]=1.[Br:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16]Br.[OH-].[Na+]>S([O-])(O)(=O)=O.C([N+](CCCC)(CCCC)CCCC)CCC.O>[Br:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][O:10][CH2:9][CH2:8][C:5]1[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=1

Komponenten

6

Edukt 3

HCID 81001,5-DibromopentaneHCID 14798Sodium HydroxideHCID 820684-Fluorophenethyl Alcohol

Produkt 1

HCID 197980301-[2-[(5-Bromopentyl)oxy]ethyl]-4-fluorobenzene

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 94433Tetrabutylammonium hydrogen sulfateKatalysatorHCID 962WaterLösungsmittel

Versuchsvorschrift

4-Fluorobenzeneethanol (10.0 g), 1,5-dibromopentane (29 ml), tetra-n-butylammonium hydrogen sulphate (3.2 g, 9 mmol), and aqueous 12.5 M NaOH (109 ml) were stirred vigorously at RT overnight. The mixture was diluted with H2O (400 ml), extracted with ER (3×200 ml), and the combined organic extracts were evaporated. The residual oil was purified by [FCS] eluting with CX-ER (100:0→100:6), to give the title compound as a colourless oil (14.37 g). T.l.c. (ER-CX, 19:1) Rf 0.22.

Aufarbeitung

  1. extractionextracted with ER (3×200 ml)
  2. customthe combined organic extracts were evaporated
  3. customThe residual oil was purified by [FCS]
  4. washeluting with CX-ER (100:0→100:6)

Quellen und Nachweise

ORD-Eintrag
ord-e69fe70ae7ca4200a4a1976a61404a61
Quelldatensatz
uspto-grants-1993_09
Patentnummer
US05243076

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