Acetic Anhydride → Diisopropylethylamine
Reaktionsgleichung
[C:1](OC(=O)C)(=O)C.C(O[C:13](=O)[CH2:14][CH3:15])(=O)CC.C([N:19]([CH2:22][CH3:23])[CH2:20][CH3:21])C.C1COCC1>C(OC(=O)C)C.C(COC)OC.C1(C)C=CC=CC=1>[CH:22]([N:19]([CH:14]([CH3:13])[CH3:15])[CH2:20][CH3:21])([CH3:23])[CH3:1]Komponenten
8
Edukt 4
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 3
Versuchsvorschrift
The amide acid VIIC is cyclized by treatment with a cyclizing agent such as acetic anhydride or propionic anhydride (employing a molar ratio of anhydride:VIIC of within the range of from about 7:1 to about 5:1) and amine base such as triethylamine or diisopropylethylamine, in the presence of an inert organic solvent such as THF, toluene, monoglyme or ethylacetate, at a temperature within the range of from about 70° to about 110° C., to form compound XXVIII.
Quellen und Nachweise
- ORD-Eintrag
- ord-6d4ad5631c0b48418e89b9ef8300b1c7
- Quelldatensatz
- uspto-grants-1997_04
- Patentnummer
- US05618946
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