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4-Methylmorpholine → 2-Bromo-5-fluoro-4-[2-methyl-1-(2-nitro-benzenesulfonyl)-aziridin-2-yl]-pyridine

HRID 538345
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Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 538345
[Br:1][C:2]1[CH:7]=[C:6]([C:8]2([CH3:11])[CH2:10][NH:9]2)[C:5]([F:12])=[CH:4][N:3]=1.P(C1C=CC=CC=1)(C1C=CC=CC=1)(C1C=CC=CC=1)=O.[N+:33]([C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][C:37]=1[S:42](Cl)(=[O:44])=[O:43])([O-:35])=[O:34].CN1CCOCC1>C1COCC1.O>[Br:1][C:2]1[CH:7]=[C:6]([C:8]2([CH3:11])[CH2:10][N:9]2[S:42]([C:37]2[CH:38]=[CH:39][CH:40]=[CH:41][C:36]=2[N+:33]([O-:35])=[O:34])(=[O:43])=[O:44])[C:5]([F:12])=[CH:4][N:3]=1
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Komponenten

7

Edukt 4

HCID 79724-MethylmorpholineHCID 13097Triphenylphosphine OxideHCID 155402-Nitrobenzenesulfonyl chlorideHCID 866680542-Bromo-5-fluoro-4-(2-methyl-aziridin-2-yl)-pyridine

Produkt 1

HCID 866680552-Bromo-5-fluoro-4-[2-methyl-1-(2-nitro-benzenesulfonyl)-aziridin-2-yl]-pyridine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittel
HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of crude 2-bromo-5-fluoro-4-(2-methyl-aziridin-2-yl)-pyridine (3.17 g as a 45% mixture with Ph3PO, 6.17 mmol) and 2-nitrobenzene-1-sulfonyl chloride (1.368 g, 6.17 mmol) in THF (23.15 mL) and H2O (7.72 mL) was added N-methylmorpholine and the reaction mixture was stirred at rt for 1.5 h. Alox neutral (2-3 spatula) was added and the reaction mixture was filtered through celite, washed with DCM and the filtrates were diluted with DCM and 1M aq. NaHCO3 soln. The phases were separated and the aq. phase was reextracted twice with DCM. The combined org. phases were dried over Na2SO4 and concentrated. Flash chromatography on silica gel (heptane:EtOAc 4:1 to 3:1) followed by recrystallization from EtOAc/hexane yielded the title compound as a colourless solid. HPLC RtH4=1.11 min; ESIMS: 416, 418 [(M+H)+]; 1H NMR (400 MHz, CDCl3): δ 8.31-8.30 (m, 1H), 8.23 (d, 1H), 7.86-7.77 (m, 3H), 7.68 (d, 1H), 3.28 (s, 1H), 2.78 (s, 1H), 2.09 (s, 3H).

Aufarbeitung

  1. additionAlox neutral (2-3 spatula) was added
  2. filtrationthe reaction mixture was filtered through celite
  3. washwashed with DCM
  4. additionthe filtrates were diluted with DCM and 1M aq. NaHCO3 soln
  5. customThe phases were separated
  6. dry with materialphases were dried over Na2SO4
  7. concentrationconcentrated
  8. customFlash chromatography on silica gel (heptane:EtOAc 4:1 to 3:1) followed by recrystallization from EtOAc/hexane

Quellen und Nachweise

ORD-Eintrag
ord-cb961b84637a4557901477a6bf53a1e8
Quelldatensatz
uspto-grants-2014_10
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US08865712B2

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