Carbon Dioxide → Lithium 4-(morpholinomethyl)thiazole-2-carboxylate

4-(Morpholinomethyl)thiazole (640 mg) was dissolved in diethyl ether (5 ml) in an argon atmosphere, and n-butyllithium (1.54N hexane solution, 2.50 ml) was added dropwise at −78° C. The reaction mixture was stirred for 10 minutes under ice cooling, and cooled again to −78° C. After blowing carbon dioxide into the reaction mixture for 20 minutes, it was heated to room temperature. The reaction mixture was concentrated under reduced pressure to obtain the title compound (873 mg) as crude yellow powder.

1. additionwas added dropwise at −78° C
2. customfor 20 minutes
3. temperatureit was heated to room temperature
4. concentrationThe reaction mixture was concentrated under reduced pressure

ORD-Eintrag

ord-64b8271cb2164c2a9604aa0661facf5e

Quelldatensatz

uspto-grants-2011_05

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07935824B2