Iodoethane → Pentafluorobenzoyl chloride

Into a 250 ml three-neck flask, which was equipped with an additional funnel and calcium chloride drying tube, were placed 4-ethoxydiphenyl ether (3.5 g), which was synthesized from p-phenoxyphenol with ethyl iodide in the presence of sodium hydroxide, aluminum chloride (5.4 g) and dried dichloroethane (30 ml). The solution of 2,3,4,5,6-pentafluorobenzoyl chloride (3.7 g), which was synthesized from 2,3,4,5,6-pentafluorobenzoic acid with thionyl chloride, and dried dichloroethane (10 ml) was slowly dripped into flask while stirring. After the addition was complete, the reaction mixture was stirred overnight at room temperature. Small amount of water was added very slowly to the reaction mixture and continued stirring for 15 min. The reaction mixture was then poured into 250 ml of water, which was extracted with dichloromethane. The organic layer was collected, washed with water, dried over sodium sulfate, filtered and evaporated. Recrystallization from methanol with charcoal yielded white crystal of 4-ethyoxy-4′-(2,3,4,5,6-pentafluorobenzoyl) diphenyl ehter (EPDE) (yield 60.4%).

1. customInto a 250 ml three-neck flask, which was equipped with an additional funnel and calcium chloride drying tube
2. customwas slowly dripped into flask
3. additionAfter the addition
4. stirringthe reaction mixture was stirred overnight at room temperature
5. stirringcontinued stirring for 15 min
6. extractionwas extracted with dichloromethane
7. customThe organic layer was collected
8. washwashed with water
9. dry with materialdried over sodium sulfate
10. filtrationfiltered
11. customevaporated
12. customRecrystallization from methanol with charcoal yielded white crystal of 4-ethyoxy-4′-(2,3,4,5,6-pentafluorobenzoyl) diphenyl ehter (EPDE) (yield 60.4%)

ORD-Eintrag

ord-61b20153c3b74c3086ad003dff9f1bf5

Quelldatensatz

uspto-grants-2001_01

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US06172181B2