Water → 4,4-Diphenylbutyl methanesulfonate

HRID 565651

Reaktionsgleichung

Reaktionsgleichung von HRID 565651
[C:1]1([CH:7]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:8][CH2:9][CH2:10][OH:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O.[CH3:19][S:20](Cl)(=[O:22])=[O:21]>ClC(Cl)C.C(N(CC)CC)C>[CH3:19][S:20]([O:11][CH2:10][CH2:9][CH2:8][CH:7]([C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1)(=[O:22])=[O:21]

Komponenten

6

Edukt 3

HCID 962WaterHCID 31297Methanesulfonyl chlorideHCID 925194,4-Diphenylbutan-1-ol

Produkt 1

HCID 138807014,4-Diphenylbutyl methanesulfonateAusbeute 99 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 63651,1-DichloroethaneLösungsmittelHCID 8471TriethylamineLösungsmittel

Versuchsvorschrift

To an iced-cooled solution of 4,4-diphenyl-1-butanol (5.6 g) in dichloroethane (100 mL), 11 mL of triethylamine and 2.9 mL of methanesulfonyl chloride were added dropwise in the order mentioned. After 30 minutes of stirring, the reaction mixture was poured into water and extracted with ethyl acetate. The extract was washed with saturated aqueous NaCl, dried over MgSO4, and concentrated to provide 7.5 g of the title compound. Yield 99%.

Aufarbeitung

  1. extractionextracted with ethyl acetate
  2. washThe extract was washed with saturated aqueous NaCl
  3. dry with materialdried over MgSO4
  4. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-c9ddfde998e143e8bc06e50cd97540c8
Quelldatensatz
uspto-grants-2001_01
Patentnummer
US06172085B2

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