2-(2,6-Difluoro-phenyl)-6-nitro-benzo[d][1,3]oxazin-4-one → 6-Amino-2-(2,6-difluoro-phenyl)-benzo[d][1,3]oxazin-4-one

HRID 567680

Reaktionsgleichung

Reaktionsgleichung von HRID 567680
[N+:1]([C:4]1[CH:22]=[CH:21][C:7]2[N:8]=[C:9]([C:13]3[C:18]([F:19])=[CH:17][CH:16]=[CH:15][C:14]=3[F:20])[O:10][C:11](=[O:12])[C:6]=2[CH:5]=1)([O-])=O>C(O)(=O)C.O=[Pt]=O>[NH2:1][C:4]1[CH:22]=[CH:21][C:7]2[N:8]=[C:9]([C:13]3[C:14]([F:20])=[CH:15][CH:16]=[CH:17][C:18]=3[F:19])[O:10][C:11](=[O:12])[C:6]=2[CH:5]=1

Komponenten

4

Edukt 1

HCID 212624642-(2,6-Difluoro-phenyl)-6-nitro-benzo[d][1,3]oxazin-4-one

Produkt 1

HCID 98603326-Amino-2-(2,6-difluoro-phenyl)-benzo[d][1,3]oxazin-4-one

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 345198Adams' catalystKatalysatorHCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

6-Nitro-2-(2,6-difluoro-phenyl)-benzo[d][1,3]oxazin-4-one (50 mg) was dissolved in acetic acid (5 mL) under N2, PtO2 (2.5 mg) was added and the mixture was hydrogenated with H2 gas. Reaction time 2 h. The reaction mixture was filtered through Hyflo®, which was rinsed afterwards with ethyl acetate. The combined organic phases were evaporated to dryness and subsequently treated three times with toluene followed by evaporation.

Aufarbeitung

  1. customReaction time 2 h
  2. filtrationThe reaction mixture was filtered through Hyflo®, which
  3. washwas rinsed afterwards with ethyl acetate
  4. customThe combined organic phases were evaporated to dryness
  5. additionsubsequently treated three times with toluene
  6. customfollowed by evaporation

Quellen und Nachweise

ORD-Eintrag
ord-d8033a7ca60b434caf3c2f39c77958ee
Quelldatensatz
uspto-grants-2001_01
Patentnummer
US06180625B2

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