Water → 3-Bromo-4-dimethylaminobenzophenone

HRID 580613

Reaktionsgleichung

Reaktionsgleichung von HRID 580613
[CH3:1][N:2]([CH3:17])[C:3]1[CH:16]=[CH:15][C:6]([C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[O:8])=[CH:5][CH:4]=1.[Br:18]Br.O.S(=O)(O)[O-].[Na+]>C(O)(=O)C.C1(C)C=CC=CC=1.O>[Br:18][C:4]1[CH:5]=[C:6]([CH:15]=[CH:16][C:3]=1[N:2]([CH3:17])[CH3:1])[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:8]

Komponenten

7

Edukt 4

HCID 962WaterHCID 107374-(Dimethylamino)benzophenoneHCID 24408BromineHCID 23665763Sodium Bisulfite

Produkt 1

HCID 201339243-Bromo-4-dimethylaminobenzophenone

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 176Acetic AcidLösungsmittel2×HCID 22272177Toluene waterLösungsmittel

Versuchsvorschrift

22.5 g (0.1 mol) of 4-dimethylaminobenzophenone were dissolved in 60 ml of acetic acid, and then a solution of 5.3 ml (0.105 mol) of bromine in 20 ml of acetic acid was added dropwise thereto over a period of one hour, while stirring. The mixture was then stirred for 30 minutes more, and some water and some sodium bisulfite for decolorization were added. The greasy substance thus obtained was shaken with toluene/water, the toluene phase was washed twice more with water and dried, and the toluene was distilled off in vacuo. Yield: 24.4 g (80% of theory); viscous oil.

Aufarbeitung

  1. stirringThe mixture was then stirred for 30 minutes more
  2. customThe greasy substance thus obtained
  3. washthe toluene phase was washed twice more with water
  4. customdried
  5. distillationthe toluene was distilled off in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-7e7e096c21da4933824590331772f5b7
Quelldatensatz
uspto-grants-1988_06
Patentnummer
US04753934

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