Water → 3beta-Acetoxyandrost-5-en-17-one

HRID 581685

Reaktionsgleichung

[CH3:1][C@@:2]12[C:10](=[O:11])[CH2:9][CH2:8][C@H:7]1[C@@H:6]1[CH2:12][CH:13]=[C:14]3[CH2:19][C@@H:18]([OH:20])[CH2:17][CH2:16][C@:15]3([CH3:21])[C@H:5]1[CH2:4][CH2:3]2.[OH2:22].N1[CH:28]=[CH:27]C=CC=1>>[C:27]([O:20][C@H:18]1[CH2:17][CH2:16][C@@:15]2([CH3:21])[C:14](=[CH:13][CH2:12][C@@H:6]3[C@@H:5]2[CH2:4][CH2:3][C@@:2]2([CH3:1])[C@H:7]3[CH2:8][CH2:9][C:10]2=[O:11])[CH2:19]1)(=[O:22])[CH3:28]

Komponenten

Edukt 3

HCID 962Water

HCID 1049Pyridine

HCID 5881Dehydroepiandrosterone

Produkt 1

HCID 147093beta-Acetoxyandrost-5-en-17-one

Versuchsvorschrift

Dehydroepiandrosterone (2.88 g, 10 mmol) is dissolved in a mixture (100 ml) of anhydride acetic and pyridine (1:1 v/v) and left at room temperature for 16 h. The mixture is then poured carefully into iced water and after 16 h, crystals are filtered and dried in vacuo.

Aufarbeitung

filtrationcrystals are filtered
customdried in vacuo

Quellen und Nachweise

ORD-Eintrag: ord-c79a7bfbb62d464b9f05a6342d845167
Quelldatensatz: uspto-grants-1999_07
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US05922700

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