Bromine → 3-(3-Bromo-4-methoxyphenyl)propanoic acid

HRID 582202

Reaktionsgleichung

Reaktionsgleichung von HRID 582202
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][C:11]([OH:13])=[O:12])=[CH:5][CH:4]=1.[Br:14]Br>C(O)(=O)C.O>[Br:14][C:8]1[CH:7]=[C:6]([CH2:9][CH2:10][C:11]([OH:13])=[O:12])[CH:5]=[CH:4][C:3]=1[O:2][CH3:1]

Komponenten

5

Edukt 2

HCID 24408BromineHCID 957503-(p-Methoxyphenyl)propionic acid

Produkt 1

HCID 45476083-(3-Bromo-4-methoxyphenyl)propanoic acidAusbeute 87 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 176Acetic AcidLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

To a solution of 3-(4-methoxyphenyl)propionic acid (4.0 g, 22.2 mmol) in acetic acid (20 ml) was added bromine (3.9 g, 24.4 mmol) gradually dropwise at 10° C. and the mixture was stirred at room temperature for 30 minutes. This reaction mixture was diluted with water and extracted with ethyl acetate. The extract was washed serially with saturated saline and water and dried over anhydrous magnesium sulfate and the solvent was distilled off under reduced pressure. The residue was washed with hexane to provide the title compound (yield 5.0 g, 87%).

Aufarbeitung

  1. extractionextracted with ethyl acetate
  2. washThe extract was washed serially with saturated saline and water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. distillationthe solvent was distilled off under reduced pressure
  5. washThe residue was washed with hexane

Quellen und Nachweise

ORD-Eintrag
ord-5ecfdcfbe9494c28b0be488c71647880
Quelldatensatz
uspto-grants-1999_07
Patentnummer
US05922771

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