Potassium Bromide → 5-bromo-1-trityl-1H-pyrazolo[3,4-b]pyridine-3-carbaldehyde

HRID 589449Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 589449
[Br:1][C:2]1[CH:3]=[C:4]2[C:10]([CH2:11][OH:12])=[N:9][N:8]([C:13]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[C:5]2=[N:6][CH:7]=1.[K+].[Br-].[O-]Cl.[Na+]>C(Cl)Cl.O.CC1(C)N([O])C(C)(C)CCC1>[Br:1][C:2]1[CH:3]=[C:4]2[C:10]([CH:11]=[O:12])=[N:9][N:8]([C:13]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)([C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=3)[C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[C:5]2=[N:6][CH:7]=1

Komponenten

7

Edukt 3

HCID 253877Potassium BromideHCID 23665760Sodium HypochloriteHCID 86701061(5-bromo-1-trityl-1H-pyrazolo[3,4-b]pyridin-3-yl)methanol

Produkt 1

HCID 867010605-bromo-1-trityl-1H-pyrazolo[3,4-b]pyridine-3-carbaldehydeAusbeute 80,7 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 2724126TempoKatalysatorHCID 962WaterLösungsmittel3×HCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

To a solution of (5-bromo-1-trityl-1H-pyrazolo[3,4-b]pyridin-3-yl)methanol (XXIII) (4.05 Kg, 8.6 mol) in DCM (97 L) was added a solution of KBr (205 g, 1.72 mol) in water (4 L). The solution was cooled to 0° C. before adding TEMPO (107.5 g, 688 mmol) and stirring for 30 min. To this solution was added a solution of KHCO3 (10.8 Kg, 107.4 mol) and aqueous 7% NaClO (13.4 L) in water (40 L). The reaction was stirred at 0° C. for 18 hours. A solution of Na2S2O3.5H2O (1.4 Kg, 5.7 mol) in water (9.1 L) was added dropwise to the reaction at 0° C. and stirred for 30 min. The aqueous layer was then separated and washed with DCM (48 L). The combined organic phases were washed with aqueous 25% NaCl (48 L), dried over Na2SO4, filtered and concentrated under vacuum. The residue was co-evaporated with 3×MeOH (20 L) and the solid was washed with 2×n-heptane (8 L). The solid was dried under vacuum at 45° C. to give 5-bromo-1-trityl-1H-pyrazolo[3,4-b]pyridine-3-carbaldehyde (XXIV) (3.25 Kg, 6.94 mol, 92.3% purity, 80.6% assay yield). 1H NMR (CDCl3, 400 MHz) δ ppm 7.19 (d, J=6 Hz, 5H), 7.22-7.34 (m, 10H), 8.28 (d, J=2.4 Hz, 1H), 8.70 (d, J=2.4 Hz, 1H), 10.07 (s, 1H); ESIMS found C26H18BrN3O m/z 490.0 (M+Na).

Aufarbeitung

  1. stirringThe reaction was stirred at 0° C. for 18 hours
  2. stirringstirred for 30 min
  3. customThe aqueous layer was then separated
  4. washwashed with DCM (48 L)
  5. washThe combined organic phases were washed with aqueous 25% NaCl (48 L)
  6. dry with materialdried over Na2SO4
  7. filtrationfiltered
  8. concentrationconcentrated under vacuum
  9. washthe solid was washed with 2×n-heptane (8 L)
  10. customThe solid was dried under vacuum at 45° C.

Quellen und Nachweise

ORD-Eintrag
ord-f0f0cb1c123c44d2a9892233f30bb7b9
Quelldatensatz
uspto-grants-2016_01
Patentnummer
US09233104B2

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