Methanol → 7-fluoro-5-methoxy-2-pyridin-4-yl-3H-quinazolin-4-one

HRID 591799Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 591799
F[C:2]1[CH:11]=[C:10]([F:12])[CH:9]=[C:8]2[C:3]=1[C:4](=[O:19])[NH:5][C:6]([C:13]1[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=1)=[N:7]2.[CH3:20][O-:21].[Na+].CO.O>CN(C=O)C.C(O)(=O)C>[F:12][C:10]1[CH:9]=[C:8]2[C:3]([C:4](=[O:19])[NH:5][C:6]([C:13]3[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=3)=[N:7]2)=[C:2]([O:21][CH3:20])[CH:11]=1

Komponenten

7

Edukt 4

HCID 887MethanolHCID 962WaterHCID 10942334Sodium MethoxideHCID 1363794005,7-difluoro-2-pyridin-4-yl-3H-quinazolin-4-one

Produkt 1

HCID 1363480537-fluoro-5-methoxy-2-pyridin-4-yl-3H-quinazolin-4-one

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 176Acetic AcidLösungsmittelHCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

To a suspension of 5,7-difluoro-2-pyridin-4-yl-3H-quinazolin-4-one (0.20 g, 0.80 mmol) in DMF (3 mL) was added sodium methoxide in methanol (0.43 g, 8.0 mmol) and the reaction mixture was stirred at room temperature for 16 hours. Water was added, the mixture was acidified with acetic acid to pH approximately 4-5, and the precipitated solid was filtered off to obtain 7-fluoro-5-methoxy-2-pyridin-4-yl-3H-quinazolin-4-one as a yellowish solid. Yield: 0.20 g (83%).

Aufarbeitung

  1. filtrationthe precipitated solid was filtered off

Quellen und Nachweise

ORD-Eintrag
ord-69d7f965874e4b4c8ae05f4b31332b45
Quelldatensatz
uspto-grants-2016_01
Patentnummer
US09238640B2

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