Bromine → HCID 118235372, Verbindung
Reaktionsgleichung
[F:1][C:2]1[CH:8]=[C:7]([S:9]([CH3:12])(=[O:11])=[O:10])[CH:6]=[CH:5][C:3]=1[NH2:4].CC([O-])=O.[K+].[Br:18]Br>CC(O)=O>[Br:18][C:5]1[CH:6]=[C:7]([S:9]([CH3:12])(=[O:11])=[O:10])[CH:8]=[C:2]([F:1])[C:3]=1[NH2:4]Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A mixture of 2-fluoro-4-methylsulfonyl-aniline (22.76 mmol) and KOAc (22.7 mmol) in AcOH was stirred at room temperature. The mixture was cooled to 0° C. and Br2 (22.7 mmol) was added dropwise. The mixture was stirred for 30 min at 0° C. The mixture was concentrated and the residue was taken up in EtOAc. The organic mixture was washed (sat. NaHCO3, sat. Na2S2O3), dried (Na2SO4) and concentrated to yield the desired product.
Aufarbeitung
- temperatureThe mixture was cooled to 0° C.
- stirringThe mixture was stirred for 30 min at 0° C
- concentrationThe mixture was concentrated
- washThe organic mixture was washed (sat. NaHCO3, sat. Na2S2O3)
- dry with materialdried (Na2SO4)
- concentrationconcentrated
Quellen und Nachweise
- ORD-Eintrag
- ord-81cfec79e52b4362b6f58408b9c46861
- Quelldatensatz
- uspto-grants-2016_09
- Patentnummer
- US09440929B2
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