Ammonia → N-tert.butyl-3,5-dibromo-2-hydroxy-benzylamine hydrochloride

HRID 616410

Reaktionsgleichung

Reaktionsgleichung von HRID 616410
[Br:1][C:2]1[CH:9]=[C:8]([Br:10])[CH:7]=[C:4]([CH:5]=O)[C:3]=1[OH:11].[C:12]([NH2:16])([CH3:15])([CH3:14])[CH3:13].N.[ClH:18]>C(O)C.CCOCC.C(O)=O>[ClH:18].[C:12]([NH:16][CH2:5][C:4]1[CH:7]=[C:8]([Br:10])[CH:9]=[C:2]([Br:1])[C:3]=1[OH:11])([CH3:15])([CH3:14])[CH3:13]

Komponenten

8

Edukt 4

HCID 222AmmoniaHCID 313Hydrochloric AcidHCID 6385Tert-ButylamineHCID 70243,5-Dibromosalicylaldehyde

Produkt 1

HCID 20308288N-tert.butyl-3,5-dibromo-2-hydroxy-benzylamine hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 284Formic AcidLösungsmittelHCID 702EthanolLösungsmittelHCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

7 gm of 3,5-dibromo-salicylaldehyde, 17.5 gm of tert. butylamine and 7.7 gm of formic acid were heated for 6 hours at 70°-80° C. Subsequently, the reaction mixture was admixed with aqueous 2 N ammonia, vigorously shaken, and the precipitate formed thereby was sucked off. The residue was dissolved in ethanol, acidified with ethanolic hydrochloric acid and admixed with ether in order to crystallize the product out. N-tert.butyl-3,5-dibromo-2-hydroxy-benzylamine hydrochloride, m.p. 216°-220° C (decomp.), was obtained after recrystallization from absolute ethanol/ether.

Aufarbeitung

  1. customthe precipitate formed
  2. customto crystallize the product out

Quellen und Nachweise

ORD-Eintrag
ord-3136111fc16f4cebb7a7f3363b4d7f1b
Quelldatensatz
uspto-grants-1978_02
Patentnummer
US04073942

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