Acetone → rac-4-chloro-3-hydroxy-2-(trans-2-hydroxycyclohexyl)-5-methoxy-6-[4-(1H-pyrazol-1-yl)benzyl]-2,3-dihydro-1H-isoindol-1-one

Reaktionsgleichung

[Cl:1][C:2]1[C:3]([CH:32]=C)=[C:4]([CH:15]=[C:16]([CH2:20][C:21]2[CH:26]=[CH:25][C:24]([N:27]3[CH:31]=[CH:30][CH:29]=[N:28]3)=[CH:23][CH:22]=2)[C:17]=1[O:18][CH3:19])[C:5]([NH:7][C@@H:8]1[CH2:13][CH2:12][CH2:11][CH2:10][C@H:9]1[OH:14])=[O:6].CC(C)=[O:36].C(#N)C.I([O-])(=O)(=O)=O.[Na+]>S([O-])([O-])(=O)=S.[Na+].[Na+].O.O.[O-][Os]([O-])(=O)=O.[K+].[K+].O>[Cl:1][C:2]1[C:17]([O:18][CH3:19])=[C:16]([CH2:20][C:21]2[CH:22]=[CH:23][C:24]([N:27]3[CH:31]=[CH:30][CH:29]=[N:28]3)=[CH:25][CH:26]=2)[CH:15]=[C:4]2[C:3]=1[CH:32]([OH:36])[N:7]([C@@H:8]1[CH2:13][CH2:12][CH2:11][CH2:10][C@H:9]1[OH:14])[C:5]2=[O:6]