Water → Methyl 5-bromo-4-ethyl-2-hydroxybenzoate

HRID 629471Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 629471
[CH2:1]([C:3]1[CH:12]=[CH:11][C:6]([C:7]([O:9][CH3:10])=[O:8])=[C:5]([OH:13])[CH:4]=1)[CH3:2].[Br:14]Br.O>C(O)(=O)C>[Br:14][C:12]1[C:3]([CH2:1][CH3:2])=[CH:4][C:5]([OH:13])=[C:6]([CH:11]=1)[C:7]([O:9][CH3:10])=[O:8]

Komponenten

5

Edukt 3

HCID 962WaterHCID 24408BromineHCID 54092218Methyl 4-ethyl-2-hydroxybenzoate

Produkt 1

HCID 118468133Methyl 5-bromo-4-ethyl-2-hydroxybenzoateAusbeute 107,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

To a solution of methyl 4-ethyl-2-hydroxybenzoate (1.43 g) in acetic acid (15.0 mL) was added bromine (1.40 g) under ice-cooling, and the mixture was stirred at room temperature for 2 hr under argon atmosphere. To the reaction mixture was added water, the resulting solid was collected by filtration, and dried under reduced pressure to give the title compound (2.21 g) as a mixture with methyl 3,5-dibromo-4-ethyl-2-hydroxybenzoate (2:1). This compound was used in the next step without an additional purification.

Aufarbeitung

  1. temperaturecooling
  2. filtrationthe resulting solid was collected by filtration
  3. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-e74eab0a62dc4172aace3357622e9356
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09315458B2

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