Hydrochloric Acid → 4-(4-Fluorophenyl)-2-hydroxy-6-methylpyrimidine

HRID 635891

Reaktionsgleichung

Reaktionsgleichung von HRID 635891
[F:1][C:2]1[CH:13]=[CH:12][C:5]([C:6]([CH2:8][C:9](=O)[CH3:10])=O)=[CH:4][CH:3]=1.[NH2:14][C:15]([NH2:17])=[O:16].Cl.C(=O)([O-])[O-].[K+].[K+]>C(O)(=O)C.O.C(O)C>[F:1][C:2]1[CH:13]=[CH:12][C:5]([C:6]2[CH:8]=[C:9]([CH3:10])[N:17]=[C:15]([OH:16])[N:14]=2)=[CH:4][CH:3]=1

Komponenten

8

Edukt 4

HCID 313Hydrochloric AcidHCID 1176UreaHCID 11430Potassium CarbonateHCID 4326551-(4-Fluoro-phenyl)-butane-1,3-dione

Produkt 1

HCID 1784227144-(4-Fluorophenyl)-2-hydroxy-6-methylpyrimidineAusbeute 46,9 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 176Acetic AcidLösungsmittelHCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of 5 g of 4-fluorobenzoylacetone, 1.66 g of urea, 25 ml of ethanol, and 3.8 ml of concentrated hydrochloric acid was refluxed for 20 hours. This reaction mixture was cooled, poured into iced water, made basic with aqueous solution of potassium carbonate, and neutralized with acetic acid. The crystals that separated out were collected by filtration, washed with isopropyl ether, and dried to provide 2.65 g of pale yellow crystals. m.p. 265-268° C.

Aufarbeitung

  1. temperaturewas refluxed for 20 hours
  2. temperatureThis reaction mixture was cooled
  3. customThe crystals that separated out
  4. filtrationwere collected by filtration
  5. washwashed with isopropyl ether
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-0c87bdaf0e5c4bbc85733afaad7cc70b
Quelldatensatz
uspto-grants-2001_02
Patentnummer
US06191149B1

Verknüpfte Notizen

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