Acetic Acid → 6-Bromo-3,4-dihydronaphthalene-1-carboxamide

HRID 63616

Reaktionsgleichung

Reaktionsgleichung von HRID 63616
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=O)[CH2:7][CH2:6][CH2:5]2.[Si]([C:17]#[N:18])(C)(C)C.[OH:19]S(O)(=O)=O.CC(O)=O>C1(C)C=CC=CC=1.[Zn+2].[I-].[I-].O>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8]([C:17]([NH2:18])=[O:19])=[CH:7][CH2:6][CH2:5]2

Komponenten

8

Edukt 4

HCID 176Acetic AcidHCID 1118Sulfuric Acid2×HCID 82115Trimethylsilyl cyanideHCID 101050696-Bromo-1-tetralone

Produkt 1

HCID 1185983436-Bromo-3,4-dihydronaphthalene-1-carboxamideAusbeute 80 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 9883512zinc(II)iodideKatalysatorHCID 962WaterLösungsmittelHCID 1140TolueneLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

To a solution of 6-bromo-1,2,3,4-tetrahydronaphthalen-1-one (5.46 g, 24.3 mmol) and ZnI2 (50 mg) in toluene (50 mL) was added TMSCN (4.82 mL, 48.6 mmol), and the solution stirred at 60° C. overnight. The reaction was cooled to rt, and H2SO4 (5.6 mL) was added. Then AcOH (34 mL), H2SO4 (25 mL) and H2O (4 mL) were added to the reaction, and it was heated to 105° C. for 3 h. The mixture was cooled and poured over ice-water (250 mL). The precipitate was collected by filtration, washed with water, and dried under vacuum to give 4.88 g (80%) of the title compound as an off-white solid. 1H NMR (400 MHz, DMSO-d6): δ 2.25-2.33 (2H, m), 2.72 (2H, t, J=8.0 Hz), 6.51 (1H, t, J=4.6 Hz), 7.20 (1H, br s), 7.35-7.40 (3H, m), 7.65 (1H, br s). [M+H] calc'd for C11H10BrNO, 252, 254. found 252, 254.

Aufarbeitung

  1. temperatureThe reaction was cooled to rt
  2. temperaturewas heated to 105° C. for 3 h
  3. temperatureThe mixture was cooled
  4. filtrationThe precipitate was collected by filtration
  5. washwashed with water
  6. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-6bb6bfdcada2480cbbd54a1d34aaccd8
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09447046B2

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