Water → 2-Bromothieno[2,3-b][1,5]benzoxazepin-4(5H)-one

HRID 650000Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 650000
[S:1]1[C:5]2[O:6][C:7]3[CH:15]=[CH:14][CH:13]=[CH:12][C:8]=3[NH:9][C:10](=[O:11])[C:4]=2[CH:3]=[CH:2]1.[Br:16]Br.O>C(O)(=O)C>[Br:16][C:2]1[S:1][C:5]2[O:6][C:7]3[CH:15]=[CH:14][CH:13]=[CH:12][C:8]=3[NH:9][C:10](=[O:11])[C:4]=2[CH:3]=1

Komponenten

5

Edukt 3

HCID 962WaterHCID 24408BromineHCID 18422172Thieno[2,3-b][1,5]benzoxazepin-4(5H)-one

Produkt 1

HCID 184221932-Bromothieno[2,3-b][1,5]benzoxazepin-4(5H)-oneAusbeute 80,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel2×

Versuchsvorschrift

Thieno[2,3-b][1,5]benzoxazepin-4(5H)-one (2 g) was suspended in acetic acid (30 ml) and a solution of bromine (1.5 g) in acetic acid (10 ml) was added dropwise over 30 minutes. The mixture was stirred at room temperature for 35 minutes and poured into water. The precipitated crystals were collected by filtration and washed with water and diisopropyl ether to give 2-bromothieno[2,3-b][1,5]benzoxazepin-4(5H)-one (2.2 g).

Aufarbeitung

  1. filtrationThe precipitated crystals were collected by filtration
  2. washwashed with water and diisopropyl ether

Quellen und Nachweise

ORD-Eintrag
ord-9668b277fa4642cf9e29602a5f9122bf
Quelldatensatz
uspto-grants-2001_08
Patentnummer
US06271225B1

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