Hydrazine hydrate (1:1) → HCID 178480237, Verbindung

HRID 652129

Reaktionsgleichung

Reaktionsgleichung von HRID 652129
F[C:2]1[CH:16]=[CH:15][CH:14]=[CH:13][C:3]=1[C:4]([CH:6]1[CH2:11][CH2:10][N:9]([CH3:12])[CH2:8][CH2:7]1)=O.O.[NH2:18][NH2:19]>O>[CH3:12][N:9]1[CH2:10][CH2:11][CH:6]([C:4]2[C:3]3[C:2](=[CH:16][CH:15]=[CH:14][CH:13]=3)[NH:19][N:18]=2)[CH2:7][CH2:8]1

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 131803174-(2-Fluorobenzoyl)-1-methylpiperidine

Produkt 1

HCID 178480237HCID 178480237, VerbindungAusbeute 23,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

An autoclave was charged with 10.0 g of 4-(2-fluorobenzoyl)-1-methylpiperidine and 14 ml of hydrazine hydrate. The reaction was heated at 150° for 20 hrs, cooled, and poured into water. The resultant solid was collected. The solid was recrystallized twice from toluene to yield 2.4 g (23.7%) of product, mp 168°-170° C.

Aufarbeitung

  1. temperatureThe reaction was heated at 150° for 20 hrs
  2. temperaturecooled
  3. customThe resultant solid was collected
  4. customThe solid was recrystallized twice from toluene

Quellen und Nachweise

ORD-Eintrag
ord-cdd33599bdaa477e8b872b2930c887a2
Quelldatensatz
uspto-grants-1987_06
Patentnummer
US04670447

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